The hunt for a flu vaccine

Daily Echo: Dr Tom Havelock Dr Tom Havelock

IT is one of the holy grails of modern medicine and would save millions of lives across the globe every winter.

Scientists in Southampton are about to start clinical trials of a new vaccine that could protect against almost multiple strains of flu – including pandemics such as swine flu.

But the team at Southampton General Hospital needs the help of the people of Hampshire to realise their potentially Noble Prize-winning dream.

They today called for volunteers to come forward to take part in the groundbreaking research, which is due to begin in just two weeks.

As the death toll from the global swine flu pandemic tops 1,000 and with 110,000 new cases diagnosed in the UK in the past week, the eyes of the world will be on the Southampton trial.

Anyone healthy and aged between 18 and 45 can take part. Initially, volunteers will have a blood test to see if they are immune to a particular strain of flu.

Dr Tom Havelock, who is co-ordinating the Southampton trial for the Wellcome Trust, said 26 people who do not have this immunity will then go ahead to trial the “universal vaccine”.

Since the Echo first reported on the trial last month about 20 of the places have been filled, but with time running out there are still remaining places.

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The challenge for the scientists is that only about one in ten candidates are suitable, as most have already been exposed to this particular strain of flu sometime in the past couple of years.

Once the 26 have been selected, Dr Havelock explained that 14 of the volunteers would be injected with the vaccine in mid-August at the hospital.

The only possible side-effects they might experience are mild flu-like symptoms and a sore arm for 24 hours, while the remaining 12 volunteers will not be vaccinated.

About one month later they will travel to a research facility in London where they will all be exposed to a strain of flu.

They will be exposed with a couple of drips into their nose and then spend the next ten days in isolation at the facility, which Dr Havelock described as a “comfortable hospital” with a vast DVD library.

If all goes to plan, those given the vaccine should only suffer very mild symptoms while the others will have to endure the flu as doctors monitor their temperature.

In return they will receive a payment, but due to ethical guidelines Dr Havelock was unable to reveal the amount.

“The one unknown that we are dealing with is that we are giving people a vaccine that will strongly boost their immune system against the flu and then we are giving them the flu,” Dr Havelock said.

“The one thing we haven’t tested in clinical trials is the effect of the immune system to the flu challenge, but this is going to be tested on two volunteers in Oxford in August prior to the big trial in Southampton. It really is very safe.”

He added: “If this technique works it is going to be really world-shattering stuff, because it could save thousands of lives in the UK alone every year and possibly lead to new vaccines for TB and malaria.”

If you are interested in taking part, contact recruitment coordinator Gemma Neal on 023 8079 6322 or email gemma.neal@suht.swest.nhs.uk.

Comments (8)

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12:33pm Sun 2 Aug 09

HowDictorial says...

Thats a No Thanks from me,,no amount of money would make me even want to do a thing like this,but with the economy the way it is at the moment i doubt very much if they will have a problem finding volunteers who are willing to subject their bodies to something as dangerous as this....
Thats a No Thanks from me,,no amount of money would make me even want to do a thing like this,but with the economy the way it is at the moment i doubt very much if they will have a problem finding volunteers who are willing to subject their bodies to something as dangerous as this.... HowDictorial
  • Score: 0

1:21pm Sun 2 Aug 09

Vonnie says...

Unfortunately, someone has to do it. I admire their courage.
Unfortunately, someone has to do it. I admire their courage. Vonnie
  • Score: 0

1:33pm Sun 2 Aug 09

freemantlegirl2 says...

I would do it, if I didn't have to catch the flu possibly :( am a fulltime carer to my two youngest who have immune deficiency so not a good idea! but I would be willing otherwise because I think these developments are very exciting :)

Absolute kudos to the team who've developed it, I hope it's successful :)
I would do it, if I didn't have to catch the flu possibly :( am a fulltime carer to my two youngest who have immune deficiency so not a good idea! but I would be willing otherwise because I think these developments are very exciting :) Absolute kudos to the team who've developed it, I hope it's successful :) freemantlegirl2
  • Score: 0

1:56pm Sun 2 Aug 09

goard says...

Most of us would remember those poor lads who did not fare well with the experiments. BUT it takes a special sort of person who can, without the thought of money forthcoming to do the experiments.
There are some very special people. Sometimes it frightens me that science is going very fast ahead - animals have been used and who knows how many have suffered death, now it is the turn of human beings - are you that special person?

goard
Most of us would remember those poor lads who did not fare well with the experiments. BUT it takes a special sort of person who can, without the thought of money forthcoming to do the experiments. There are some very special people. Sometimes it frightens me that science is going very fast ahead - animals have been used and who knows how many have suffered death, now it is the turn of human beings - are you that special person? goard goard
  • Score: 0

2:13pm Sun 2 Aug 09

King Mush says...

'Noble' Prize? lol

I thought that was only given out for discovering new gases?

Anybody remember Porton Down? As mentioned - it does take a special kind of person to act as a human guinea pig though.


At least it might bring up the never ending war on unnecessary vivisection which has meant long drawn out torture and death after years of being crammed into a cage.


Millions of creatures have suffered 'in the name of research' admittedly with a slight degree of success.


However - us humans are so genetically far removed from sub species and we all know how futile much of the research has been.


At least it keeps scientists in a fairly well paid 'job'

Anyway - there is an easier way to grab some Tamiflu right now. Try e-bay!


You may have read about the Bristol bozo who sold his kids' unwanted vaccine on e-bay and ended up being stung by an undercover MOS reporter!


Bless......
'Noble' Prize? lol I thought that was only given out for discovering new gases? Anybody remember Porton Down? As mentioned - it does take a special kind of person to act as a human guinea pig though. At least it might bring up the never ending war on unnecessary vivisection which has meant long drawn out torture and death after years of being crammed into a cage. Millions of creatures have suffered 'in the name of research' admittedly with a slight degree of success. However - us humans are so genetically far removed from sub species and we all know how futile much of the research has been. At least it keeps scientists in a fairly well paid 'job' Anyway - there is an easier way to grab some Tamiflu right now. Try e-bay! You may have read about the Bristol bozo who sold his kids' unwanted vaccine on e-bay and ended up being stung by an undercover MOS reporter! Bless...... King Mush
  • Score: 0

4:04pm Mon 3 Aug 09

now in the north says...

For all those of you willing to take the flu vaccine...you can go in front of me!! Roll up your sleeves...
In 1976, there was a 'swine flu' pandemic. The government invested thousands in adverts and vaccines for everyone.
There is a 60minute progarm on youtube from back then about it. Infact, the vaccine was sold on the fact the swine flu had killed a solider...one of only five in the platoon to have gotten swine flu. He was sent on a forced march/parade whilst being ill with flu and collapsed and died.
So, the goevernments stance was, if it can kill a healthy soldier, it can kill anyone. (incidently, like lots of other viruses, they started in a military unit)
The vaccine was tested and 'proved' safe but this was not the vaccine that was given as the mutations of the virus mean they quickly become useless.
The swine flu claimed just that one life...the vaccine claimed 300! 4000 in the US are claimed damages, mostly for neurological problems and death.
And there were all the other complications, things like Guillain-Barré syndrome, systemic lupus, arthritits etc.
The government estimated 60 million deaths worldwide from the same flu as 1918 which has been reported as h1n1 and h5n1 and then variations and combinations of these.
The vacincation game is controlled by government, the members of whom have shares in the companies making them at a time when nothing but medicine is making any money due to the financial climate.
It's a sham.
The vit K saves 1 in 100,000 children from a brain bleed but causes lukemia in 1 in 500 and also causes jaundice(midwifery Journal)
It is estimated by the producers of the annual flu vacinne that 5 consecutive flu jabs will increase the chances of alziemers by 10 times.
There have been aroud 300,000 reports of serious adverse side effects.
Baxters, creators of the vaccine have been given legal immunity meaning they cannot have legal action taken against them if it all goes wrong. They were also the ones to accidently put live birdflu into the standard flu shot while getting the contract to make the bird flu vaccine(http://www.t
orontosun.com/news/c
anada/2009/02/27/856
0781.html)incidently
, they are the ones who have the swine flu vacination contract too.
Those people offereing themselves up for the vaccine are those who are supposed to cause the most expense to society, ie the sick and disabled, the old and young children.
To remind you, there will be little or no pension for us lot, people are living longer and costing more in retirement, the retirement age has risen and is set to rise again...meaning you will work till you die. It is slavery. Yes, these people are that bad. (check out the georgia guidestones.)
The vaccines are full of vile stuff, mercury (thermasol), washed sheep blood cells, chick embryo, calve embryo cells, fetal tissues, squalene, all jabbed straight into your body...mmmmm yummy.
Whats more, you wont have a choice...http://news
.scotsman.com/latest
news/Everyone-in-the
-UK-to.5452124.jp
But dont worry, you can trust them, they aren't doing it for money, they are doing it because they love their job, just like you do (thats sarcasm, if you really do love your job then I can bet you dont get paid much!)
Roll-up, roll-up your sleeves, the circus has come to town...


I truely believe

For all those of you willing to take the flu vaccine...you can go in front of me!! Roll up your sleeves... In 1976, there was a 'swine flu' pandemic. The government invested thousands in adverts and vaccines for everyone. There is a 60minute progarm on youtube from back then about it. Infact, the vaccine was sold on the fact the swine flu had killed a solider...one of only five in the platoon to have gotten swine flu. He was sent on a forced march/parade whilst being ill with flu and collapsed and died. So, the goevernments stance was, if it can kill a healthy soldier, it can kill anyone. (incidently, like lots of other viruses, they started in a military unit) The vaccine was tested and 'proved' safe but this was not the vaccine that was given as the mutations of the virus mean they quickly become useless. The swine flu claimed just that one life...the vaccine claimed 300! 4000 in the US are claimed damages, mostly for neurological problems and death. And there were all the other complications, things like Guillain-Barré syndrome, systemic lupus, arthritits etc. The government estimated 60 million deaths worldwide from the same flu as 1918 which has been reported as h1n1 and h5n1 and then variations and combinations of these. The vacincation game is controlled by government, the members of whom have shares in the companies making them at a time when nothing but medicine is making any money due to the financial climate. It's a sham. The vit K saves 1 in 100,000 children from a brain bleed but causes lukemia in 1 in 500 and also causes jaundice(midwifery Journal) It is estimated by the producers of the annual flu vacinne that 5 consecutive flu jabs will increase the chances of alziemers by 10 times. There have been aroud 300,000 reports of serious adverse side effects. Baxters, creators of the vaccine have been given legal immunity meaning they cannot have legal action taken against them if it all goes wrong. They were also the ones to accidently put live birdflu into the standard flu shot while getting the contract to make the bird flu vaccine(http://www.t orontosun.com/news/c anada/2009/02/27/856 0781.html)incidently , they are the ones who have the swine flu vacination contract too. Those people offereing themselves up for the vaccine are those who are supposed to cause the most expense to society, ie the sick and disabled, the old and young children. To remind you, there will be little or no pension for us lot, people are living longer and costing more in retirement, the retirement age has risen and is set to rise again...meaning you will work till you die. It is slavery. Yes, these people are that bad. (check out the georgia guidestones.) The vaccines are full of vile stuff, mercury (thermasol), washed sheep blood cells, chick embryo, calve embryo cells, fetal tissues, squalene, all jabbed straight into your body...mmmmm yummy. Whats more, you wont have a choice...http://news .scotsman.com/latest news/Everyone-in-the -UK-to.5452124.jp But dont worry, you can trust them, they aren't doing it for money, they are doing it because they love their job, just like you do (thats sarcasm, if you really do love your job then I can bet you dont get paid much!) Roll-up, roll-up your sleeves, the circus has come to town... I truely believe now in the north
  • Score: 0

4:08pm Mon 3 Aug 09

now in the north says...

Please, excuse the spellings and typo's...I do get tired of informing people...
Please, excuse the spellings and typo's...I do get tired of informing people... now in the north
  • Score: 0

5:50pm Tue 4 Aug 09

Redback says...

I expect the tinfoil hat obsures your view of the keyboard somewhat as well.
I expect the tinfoil hat obsures your view of the keyboard somewhat as well. Redback
  • Score: 0

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