Saints' trip to Liverpool on the opening weekend of the season is one of three matches picked for live television coverage.
Ronald Koeman will now take his side to Anfield on Sunday, August 17, for a 1.30pm kick-off.
Saints will face a reunion with Rickie Lambert and Adam Lallana that day, after both players were sold to the Reds this summer.
The club's visit to Aston Villa has also been moved, and will now take place on Monday, November 24, at 8pm.
Saints' home game against Manchester City has also been switched for television, and will now take place at 1.30pm on Sunday, November 30.
All three games will be shown by Sky Sports.
As a result of the Manchester City match being changed, Saints' visit to Arsenal has been pushed back by 24 hours and will now take place on Wednesday, December 3, at 7.45pm.