Everton top scorer Romelu Lukaku will face a fitness test tomorrow, to determine whether he plays against Saints this weekend.
The striker has been struggling with a hamstring injury and is rated as 50-50 by Blues manager Roberto Martinez.
Everton also have doubts over Darron Gibson, as well as Kevin Mirallas and Steven Pienaar, while Bryan Oviedo and Tony Hibbert are definitely out.
Arouna Kone is fit to play, however, if Lukaku misses out, after recovering from knee and ankle knocks.
Martinez said: "We had three knocks at QPR.
"Of those, Darron Gibson and Romelu missed their international matches and Romelu will have a fitness test tomorrow. He's 50-50.
"Darron Gibson hasn't joined the group yet, but we're hopeful he could make it for weekend and Arouna Kone is 100 per cent fit – he trained yesterday.
"Kevin Mirallas has joined the group again and we're going to assess him, and the same for Steven Pienaar. We'll see how those two do in the next two days.
"Tony Hibbert and Bryan Oviedo are definitely out."
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