Liam Dawson starred with bat and ball as the South clinched the North-South Series with a match to spare with a 47-run victory at the Dubai International Cricket Stadium.
The Hampshire all-rounder made an 83-ball 68 before taking 2-46 from ten overs as the South (346-6) beat the North (299-9) by 47 runs.
Sam Northeast made an unbeaten 118, and shared the matchwinning partnership of 170 with Dawson, after the South were put in by North captain Keaton Jennings – with Dawid Malan adding an authoritative 78 to the unbeaten century he scored in the opening game on Thursday.
Ben Duckett gave the North the flying start they needed in reply, racing to a 32-ball half century and sharing a third-wicket stand of 74 with Liam Livingstone which contained the most absorbing cricket of the series.
But after Toby Roland-Jones had Livingstone well caught by Steven Finn off a top-edged hook, Dawson claimed the key wicket of Duckett for 64, and the Hampshire star went on to earn figures of two for 46 in his second tidy spell of the series – although they were slightly dented by Tim Bresnan, who thumped a typically defiant 74 from 66 balls to reduce the North’s margin of defeat.
The South will now be aiming for a 3-0 whitewash when the series concludes in Abu Dhabi on Tuesday.
Both sides made two changes from the first game, with Hampshire's Tom Alsop and Tim Groenewald replacing Lewis Gregory and Mason Crane for the South, and Josh Poysden and Saqib Mahmood making their North debuts as Mark Wood and Graeme White took a rest.
Bresnan gave the North the perfect start after Jennings had chosen to field in roasting heat, opening up with a maiden which ended with Daniel Bell-Drummond edging a drive to Joe Clarke.
That was the first wicket the South had lost in the series and after watching Malan and Bell-Drummond seal a 10-wicket win on Thursday their captain James Vince made an immediate impression as he stroked 46 from 41 balls in a second-wicket stand of 113 with Malan.
But the North’s spinners pegged back the South, with Vince bowled by Livingstone, Poysden bowling a tidy eight-over spell, and Yorkshire’s Jack Leaning claiming the wickets of Malan and Alsop in consecutive overs with his occasional off-spin.
That left the South under pressure for the first time in the series at 142 for four. But Dawson joined Northeast to strike 83 from 68 balls with five fours and three sixes.
He holed out to long-off, giving Harry Gurney his first wicket of the series, but Northeast moved on to his third List A century, seizing his first chance to impress the England head coach Trevor Bayliss who was again watching with selectors James Whitaker and Mick Newell.
Finn and Tom Curran claimed early wickets when the North replied under the floodlights, Sam Hain edging Finn to Ben Foakes, and Curran pinning his England Lions captain Jennings lbw.
Curran’s second ball at Livingstone was a no-ball which the Lancashire right-hander edged wide of second slip for four – and he then dispatched the free hit over extra cover for six into the corporate seats.
Livingstone added a second six over long leg off Finn, while Duckett combined improvisation with some more orthodox shots in hitting nine fours and a six.
But their dismissals left the North with a mountain to climb, and despite promising starts from Clarke and Leaning, only Bresnan played an innings of substance – and by then it was far too late.
Dawson said: “At the start of the series we said we wanted to win every game and win 3-0, and we’re going to Abu Dhabi with a chance to do that.
“We were under a little of pressure when I came in, and the partnership that me and Sam put on was a good one.
“It was tough for everyone in the heat, and Sam took his opportunity really well.
“I’ve carried a lot of drinks this winter, I haven’t played much cricket, so to come here and show what I can do, I’m obviously very happy with that.
“It’s been an exciting winter to be involved in all the formats, great to be around, but obviously you want to play cricket as well, so to come here and play three games and do well so far feels good.
“Who knows what squad England will pick for the Champions Trophy? All you can do is keep putting performances in. Hopefully I can do that again in the third game in Abu Dhabi, and when I go back to county cricket with Hampshire, put in some strong white-ball performances and see where I end up.
“It’s a good concept. It gives people an opportunity to play, and it’s shown already we’ve had two good games.”
Sam Northeast said: “I’ve batted with Daws (Liam Dawson) quite a bit. I played England Under-19s with him growing up, so we get on pretty well.
"We communicated what we thought was a good score, we said 320-330, kept it ticking over, then said let’s go and have a bit of fun, and we did really. And we ended up getting 340 which was brilliant.
"It was a good wicket, what Farby and Andy Flower have said is go out there and express yourself, don’t have any fear of failure, just go out there and have a good time."