Saints' first Premier League fixture of the season at champions Manchester City has been switched to Sunday for live coverage on Sky Sports.
The match is one of four fixtures that Sky will show before the end of November.
The City game has been bumped to Sunday, August 19, with 1 4pm kick.
Saints' home game against Manchester United finds itself in the same time slot on Sunday, September 2.
Also changed is the visit of Fulham, which now kicks-off at 1.30pm on Sunday, October 7, while the trip to West Brom is a Monday night game with an 8pm kick-off on Monday, November 5.
Also altered is Saints' home game against Tottenham which will now be on Sunday, October 28, with a 3pm kick-off. This game is not televised but moved due to Spurs' involvement in the Europa
The away trip to Manchester United has also been pushed back a day to Wednesday, January 30, with an 8pm start time.
All of Saints' initial televised games are on Sky Sports with ESPN not picking any of their matches amongst the 11 they will be broadcasting before the end of November.