The transfer window opens today, allowing Saints and their 19 fellow Premier League sides one last chance to tinker with their squads for the rest of the 2012-13 season.
Here, the Daily Echo assesses the potential arrivals and departures at each of the 20 clubs in the top flight.
Manager Arsene Wenger is looking to strengthen across the board to breathe fresh life into Arsenal's push for a top four finish. A striker tops Wenger's shopping list, with David Villa a possible target.
POTENTIAL DEPARTURES: Marouane Chamakh, Andrey Arshavin, Andre Santos, Johan Djourou, Sebastien Squillaci.
Aston Villa manager Paul Lambert spent £23million during the summer, placed his trust in youth and fielded the youngest ever Premier League side this season with an average age of less than 24. Manchester City's 20-year-old striker John Guidetti is a possible loan target while Dnipro's £2million-rated midfielder Derek Boateng is also on Lambert's radar.
POTENTIAL DEPARTURES: Darren Bent, Charles N'Zogbia.
Interim manager Rafael Benitez has all but confirmed Chelsea are trying to sign a new striker but it remains to be seen whether they will spend big on the likes of Radamel Falcao or look for a cut-price alternative, such as Demba Ba, David Villa or Alvaro Negredo. A new midfielder could also arrive.
POTENTIAL DEPARTURES: Daniel Sturridge, Florent Malouda, Yossi Benayoun.
Financial constraints mean David Moyes does not expect to be busy in the window but he would ideally like to add some more firepower if he can and has been looking at Paris St Germain striker Kevin Gameiro.
POTENTIAL DEPARTURES: John Heitinga.
The departures of Mousa Dembele and Clint Dempsey late in the summer window have left Fulham light, meaning a central midfielder and centre-back are vital additions.
POTENTIAL DEPARTURES: Pajtim Kasami, Brede Hangeland, David Stockdale, Csaba Somogyi and Mickael Tavares.
Manager Brendan Rodgers has admitted he does not have much to spend in January and a deal for Chelsea forward Daniel Sturridge, which is virtually done, will take up the vast chunk of his budget. Blackpool winger Tom Ince is the other signing the club are hopeful of wrapping up early on while Rodgers continues to be linked with Birmingham's Jack Butland despite saying he would not be signing a goalkeeper in January.
POTENTIAL DEPARTURES: Joe Cole, Stewart Downing, Jordan Henderson, Sebastian Coates.
Roberto Mancini has repeatedly played down speculation he could dip into the market but it will not go away and there is a feeling fresh blood could add impetus to City's title challenge, although some high earners might have to be moved on first.
POTENTIAL DEPARTURES: Mario Balotelli, Edin Dzeko, Kolo Toure, Joleon Lescott.
Sir Alex Ferguson says he is happy with his squad and January is not a time when he does a lot of business. But don't discount a new signing, even if the actual player does not arrive until the summer.
POTENTIAL DEPARTURES: Angelo Henriquez, Federico Macheda.
Alan Pardew knows he needs at least one, if not two or three additions to a squad ravaged by injuries during the opening half of the campaign with Marseille striker Loic Remy, Lille full-back Mathieu Debuchy and FC Twente defender Douglas among his major targets, although much will depend on whether or not Demba Ba remains on the books at the end of January.
POTENTIAL DEPARTURES: Demba Ba, Xisco, Nile Ranger.
Norwich could look to add another striker to their squad as they have managed only 20 goals so far in the league. A move for a goalkeeper is a possibility with England international John Ruddy sidelined following a groin operation.
POTENTIAL DEPARTURES: Elliott Ward, Marc Tierney, Simon Lappin, Steve Morison.
Where do we start? QPR's miserable season is due in no small part to their completely unbalanced squad. Nicolas Anelka is being targeted to fill the large void in attack, while central defence is another area requiring improvements.
POTENTIAL DEPARTURES: Jose Bosingwa, Esteban Granero, Hogan Ephraim, Rob Hulse, Jay Bothroyd.
The realisation at Reading that they failed to strengthen sufficiently during the summer may have come too late. Manager Brian McDermott is looking for two to three players with top-flight experience. Expect Andrey Arshavin to be one of them.
POTENTIAL DEPARTURES: None.
Saints' defence may have improved recently but a centre-back is still a high priority. A new goalkeeper could be a wily addition, while more attacking options would not go amiss with survival in mind.
Boss Tony Pulis has made it clear he has no intention of letting any of his key players - such as skipper Ryan Shawcross or goalkeeper Asmir Begovic - leave in January, while indicating he will be looking to "bring one or two in".
POTENTIAL DEPARTURES: Wilson Palacios, Cameron Jerome, Rory Delap.
Martin O'Neill has made no secret of his desire to strengthen further in January. Striking a permanent deal for on-loan Tottenham full-back Danny Rose could be a focus, and he has also been linked with a move for Genoa defender Andreas Granqvist, while extra physicality in central midfield is something he feels he needs to add.
POTENTIAL DEPARTURES: Titus Bramble, Matthew Kilgallon, Fraizer Campbell, Ji Dong-won.
Swansea manager Michael Laudrup is keen to bring in a striker to allow top scorer Michu to return to his favoured attacking midfielder role. Celta Vigo's Iago Aspas and Sporting Braga's Ederzito Lopes are thought to be at the top of the Dane's wishlist.
POTENTIAL DEPARTURES: Danny Graham, Luke Moore, Mark Gower, Leroy Lita, Jazz Richards, Alan Tate.
Manager Andre Villas-Boas says he will not be active in the transfer market, but he only has two recognised strikers and could therefore make a move for Shakhtar Donetsk forward Willian, Athletic Bilbao's Fernando Llorente or Loic Remy of Marseille.
POTENTIAL DEPARTURES: Carlo Cudicini, Heurelho Gomes, David Bentley, Jermaine Jenas, Danny Rose, Tom Huddlestone.
Baggies boss Steve Clarke has constantly made it clear he is happy with the squad at his disposal for the remainder of the season after climbing into the top six of the Barclays Premier League and any additions are likely to be only loanees.
POTENTIAL DEPARTURES: Chris Wood.
Manager Sam Allardyce has already been linked with big-name players such as David Beckham and Nicolas Anelka but knows the club's wage structure could scupper such deals. A loan move for an attacking player could go ahead following Yossi Benayoun's return to parent club Chelsea.
POTENTIAL DEPARTURES: None.
The January transfer window is a welcome arrival for Wigan boss Roberto Martinez, who has been contending with an injury crisis. Midfielder Roger Espinoza's transfer from Sporting Kansas City has already been completed while a loan deal for Manchester United striker Angelo Henriquez is almost a done deal. The Latics have also been linked with former Chelsea striker Salomon Kalou, now at Lille, and Manchester City midfielder Abdisalam Ibrahim.
POTENTIAL DEPARTURES: Franco Di Santo.