Due to being knocked out of the FA Cup by Derby, Ralph Hasenhuttl’s side have had a mini-break ahead of tonight’s clash.
In their last Premier League fixture, Saints overcame Everton at St Mary’s to begin their climb away from the bottom three.
A win tonight would mean three victories on the bounce and would move them up to 14th in the table.
Saints beat Palace in the reverse fixture, which proved to be ex-boss Mark Hughes’ only Premier League win this season before getting sacked
Check out pictures of the action and fans in the gallery above.
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