HUNDREDS of people will take to the streets on Friday in a protest march against plans for 1,650 homes on the former Vosper Thornycroft site.
They will parade through the city centre before handing over a detailed objection to the council's planning chief and mayor.
Campaigners have already sent out 6,000 leaflets warning that plans for the £500m development by Crest Nicholson could end in "disaster" for Woolston.
It proposes 148 houses and 1,505 flats, some of which will rise up to 25 storeys in three landmark towers. The development also includes a public plaza, shops, a supermarket, a hotel and 1,400 residential car park spaces.
Luxury US boat-builder Palmer Johnson has also submitted plans to create 800 new jobs by building a new manufacturing facility on the former VT site.
March organiser Jane Foster, of Woolston Community Association, said: "We are protesting against high-rise flats and the amount of housing, the density of housing and the traffic and access issues we will get if we have another 4,000 people living here."
She also claimed the development would devalue surrounding properties and lead to a loss in quality of life for residents.
Labour ward councillors Richard Williams, Carol Cunio and Warwick Payne are also objecting.
A water taxi, junction improvements and cycling schemes are proposed.
Crest Nicholson said the mix and number of homes was in line with council policy.
The march will take place from the Cenotaph at 4pm. The deadline for objections is now May 22.
In a statement Crest Nicholson said the Woolston community had been "instrumental" in "informing" its plans and "extensive consultation" had been carried out among residents.
Southampton and Fareham Chamber of Commerce and lobby group Business Southampton have welcomed the economic boost the development will bring to the city.
