The novelist departed from her home in Chawton to be nearer her doctor in Winchester on May 24, 1817.
Two months later on July 18 she died in a house in College Street.
Ms Worsley will lay flowers at Jane Austen’s House Museum by the memorial plaque first unveiled on July 18, 1917.
With funding from the Jane Austen Society of North America, the plaque has recently been conserved in time for the bicentenary commemorations.
Ms Worsley is author of Jane Austen At Home, published today, by Hodder & Stoughton.
Jane Austen’s House Museum is an independent museum dedicated to the life and work of Jane Austen, one of the most popular and important novelists that England has ever produced.
It is of international importance as the place where she spent the last eight years of her life and wrote or revised all her novels.
A site of significant cultural relevance and a unique source of information on the life and works of Jane Austen, the house retains the charm of a Hampshire village home.
To mark 200 years since Jane Austen’s death, the museum has launched Jane’s Fund, an appeal to restore and protect the writer’s precious home.