Morgan Schniederlin will miss Saints’ trip to Everton on Sunday after picking up his fifth booking of the season.
The midfielder was yellow carded during the 3-0 victory at Cardiff, a fifth caution of the campaign which leads to a one game ban.
Jose Fonte avoided the same fate and now only needs to avoid a booking at Everton to get past the end of year cut off when the bar raises to ten bookings for a ban.
Dejan Lovren should be fit to face Everton.
He was a late drop out of the Saints squad to face Cardiff through an illness which saw him sent home before the match.
Kelvin Davis was fit enough to return to the bench while Luke Shaw was also back in the team.
Dani Osvaldo is technically available for selection after Saints appealed his violent conduct charge from the FA and, like Nathaniel Clyne, is touch and go to be fit for the game at Goodison Park at the weekend.
Both just failed to make the game at Cardiff.