Saints keeper Fraser Forster took part in England's first training session since their World Cup campaign this morning, but just 10 outfield players were deemed fit enough to take part.
Jack Colback, Alex Oxlade-Chamberlain, Danny Rose and Gary Cahill suffered injuries over the weekend and were therefore excluded from Monday's session at London Colney.
The England medical team will assess the four players before deciding whether any replacements are needed ahead of Wednesday's friendly against Norway.
Manager Roy Hodgson is already without 12 senior players, so he will be hoping for no more withdrawals.
Fabian Delph, Calum Chambers, Daniel Sturridge, Raheem Sterling and Jordan Henderson all undertook light recovery sessions indoors, because they played for their respective clubs on Sunday.
The other 13 players, including goalkeepers Joe Hart, Ben Foster and Forster, trained as normal on a wet morning at Arsenal's Hertfordshire training base.
England, who finished bottom of their World Cup group, face Norway at Wembley on Wednesday and then fly to Basle five days later to take on Switzerland in their first Euro 2016 qualifier.
As a result of England's poor World Cup showing, the Football Association is expecting a record low crowd of 35,000-40,000 at Wembley on Wednesday.