The Saints legend will turn out for the Luey Jacob Sharp Foundation at an event in Doncaster.
Sharp, a former Sheffield United and Doncaster Rovers player who is currently on loan at Nottingham Forest, established the charity with his partner Jade Fair in memory of their son Luey Jacob Sharp who died last year at two days old.
The foundation wants to help families affected by gastroschisis, a condition usually picked up by week 14 in pregnancy and the cause of which is still unknown. It wants to raise awareness and is campaigning for care of pregnant mothers carrying babies with the condition.
The dinner, at the Keepmoat Stadium in Doncaster on November 14, will help it continue its work. Former team-mates from Sharp's previous clubs will also be at the dinner which will be hosted by Seth Bennett from BBC Radio Sheffield.
Jade, chief executive of the Luey Jacob Sharp Foundation, said: "We have been working really hard to ensure our first charity dinner is a huge success and raises much-needed funds for our foundation.
"We are delighted to be holding the dinner at the Keepmoat Stadium and would like to say a big thank you to Doncaster Rovers for hosting the event and for all the support they have given us.
"It has recently been the first anniversary of Luey's passing. We are incredibly passionate about the charity and hope that the event will be well attended and will increase awareness about gastroschisis."
The night will also feature an auction with signed lots from Jessica Ennis, Wayne Rooney, Sergio Aguero and Stuart Broad.
Tickets for the event, which includes a three-course meal, cost £40+VAT and are available from Doncaster Rovers by calling 01302 764665.